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pyrazoline: Salicylates






Salicylates:
- One of salicylate is aspirin, and also sodium salicylate, methyl salicylate, etc., pharmacokinetics
: - Route of administration: oral, rectal, parenteral
- Transportation: preotenias joined
- Average life: short.
- anti-inflammatory dose: 12 hours
- Debugging hepatic metabolism, renal excretion

- Pharmacodynamics Mecanismod and action: salicylates decrease the production and release of prstaglandinas (which produce gastric mucus)
-Pharmacological action: - Analgesia
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Antipiresis - Anti-inflammatory
- uricosuric, promotes the secretion of uric acid
- Mixed reactions "GI: nausea, vomiting, gastric ulcer, erosive gastritis, bleeding.
-blood: altered platelet function, prolonged bleeding time (no clot is formed)
- pregnancy, prolonged gestation time
- Renal blood flow decreased and filtration
Interactions with alcohol, can cause gastrointestinal bleeding ; also enhances the effect of anticoagulants.